Evaluation of anticancer effects and enhanced doxorubicin cytotoxicity of xanthine derivatives using canine hemangiosarcoma cell lines.

@article{Motegi2013EvaluationOA,
  title={Evaluation of anticancer effects and enhanced doxorubicin cytotoxicity of xanthine derivatives using canine hemangiosarcoma cell lines.},
  author={Tomoki Motegi and Masaaki Katayama and Yuji Uzuka and Yasuhiko Okamura},
  journal={Research in veterinary science},
  year={2013},
  volume={95 2},
  pages={600-5}
}
Methylxanthine derivatives increase cAMP and are known to have diuretic, cardiac, and central nervous system stimulatory effects. Moreover, caffeine inhibits the development of tumors induced by various carcinogens. The aim of this work was to elucidate the anticancer effects on apoptosis of xanthine derivatives alone and with doxorubicin in canine hemangiosarcoma cells. Xanthine derivatives with or without doxorubicin were administered to cells, and the effects were investigated by measuring… CONTINUE READING
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