Evaluation of anti-cyclic citrullinated peptide antibodies may be beneficial in RF-negative juvenile idiopathic arthritis patients

@article{Sprchez2015EvaluationOA,
  title={Evaluation of anti-cyclic citrullinated peptide antibodies may be beneficial in RF-negative juvenile idiopathic arthritis patients},
  author={Mihaela Sp{\^a}rchez and Nicolae Miu and Claudia Bolba and Mihaela Iancu and Zeno Sp{\^a}rchez and Simona Rednic},
  journal={Clinical Rheumatology},
  year={2015},
  volume={35},
  pages={601-607}
}
Despite the high diagnostic and prognostic performance in adult rheumatoid arthritis, the role of antibodies to cyclic citrullinated peptide (anti-CCP) in juvenile idiopathic arthritis (JIA) is controversial. Occurrence of anti-CCP was mainly seen in rheumatoid factor (RF)-positive polyarthritis patients. In the present study, our aim was to investigate the prevalence and significance of anti-CCP for subjects with JIA in our population. We evaluated anti-CCP reactivity in the sera of 70… CONTINUE READING