Evaluation of an oral uracil loading test to identify DPD-deficient patients using a limited sampling strategy.

Abstract

AIM Dihydropyrimidine dehydrogenase (DPD) deficiency can lead to severe toxicity following 5-fluorouracil (5FU) or capecitabine (CAP) treatment. Uracil (U) can be used as a probe to determine systemic DPD activity. The present study was performed to assess the sensitivity and specificity of a U loading dose for detecting DPD deficiency. METHODS Cancer… (More)
DOI: 10.1111/bcp.12821

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