Evaluation of an improved general unknown screening procedure using liquid chromatography-electrospray-mass spectrometry by comparison with gas chromatography and high-performance liquid-chromatography--diode array detection.

@article{Saintmarcoux2003EvaluationOA,
  title={Evaluation of an improved general unknown screening procedure using liquid chromatography-electrospray-mass spectrometry by comparison with gas chromatography and high-performance liquid-chromatography--diode array detection.},
  author={F Saint-marcoux and G{\'e}rard Lach{\^a}tre and Pierre Marquet},
  journal={Journal of the American Society for Mass Spectrometry},
  year={2003},
  volume={14 1},
  pages={
          14-22
        }
}
This paper presents an improved, comprehensive liquid chromatography-electrospray-mass spectrometry (LC-ES-MS) general unknown screening (GUS) procedure for drugs and toxic compounds and its comparison with conventional techniques in routine laboratory conditions. Chromatographic separation involved an X-TERRA MS C18, 3.5 microm (100 mm x 1 mm i.d.) column together with a 25-min long gradient of acetonitrile in pH 3, 2 mM ammonium formate delivered at a 50 microl/min flow rate. Two different in… CONTINUE READING
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