Evaluation of amino acids as mediators for the antibacterial activity of iodine-lithium-alpha-dextrin in vitro and in vivo.

  title={Evaluation of amino acids as mediators for the antibacterial activity of iodine-lithium-alpha-dextrin in vitro and in vivo.},
  author={Tigran K. Davtyan and Isabelle S Hakobyan and Rafael Muradyan and Hrachya G Hovhannisyan and Emil S Gabrielyan},
  journal={The Journal of antimicrobial chemotherapy},
  volume={59 6},
OBJECTIVES The systemic therapeutic application of iodophores has not yet been accepted due to limited availability of safe and effective ionized iodine preparations. Here we evaluated the antibacterial activity of iodine-lithium-alpha-dextrin (ILalphaD) both in vitro and in vivo. METHODS The MIC values of ILalphaD against 189 bacterial isolates in various growth media and in vivo toxicity and protective efficacy of ILalphaD in preventing mortality of rats infected with Staphylococcus aureus… 
In Vitro Evaluation of the Interaction of Dextrin-Colistin Conjugates with Bacterial Lipopolysaccharide.
Results showed that colistin and amylase-activated dextrin-colistin conjugate to a lesser extent induced aggregation of LPS to form a stacked bilayer structure with characteristic dimensions, although this did not cause any substantial change in its secondary structure.
In vitro evaluation of the structural and physical interaction of ‘ nanoantibiotic ’ dextrin-colistin conjugates with bacterial endotoxins
The results showed that colistin, and ‘amylase-activated’ dextrin-colistin conjugate to a lesser extent, bound to LPS and induced significant conformational changes to its structure, providing insight into the mode of action of dextrincolist in conjugates.
Investigations of genotoxic activity of the antimicrobial/ antiviral agent FS-1 in rodents by means of the micronucleus and the comet assays
The fact that the compound neither induces DNA damage in various organs of mice nor is effective in the induction of MN in bone marrow cells of rats and mice is important for future genotoxicity studies of FS-1, which can be used in clinical medicine after additional testing of safety for humans.
Mechanisms of the action of povidone-iodine against human and avian influenza A viruses: its effects on hemagglutination and sialidase activities
Mechanisms of reduction of viral growth in MDCK cells by PVP-I involve blockade of viral attachment to cellular receptors and inhibition of viral release and spread from infected cells to prevent infection and limit spread of human and avian influenza viruses.
Asymmetric synthesis of alpha-amino acids: preparation and alkylation of monocyclic iminolactones derived from alpha-methyl trans-cinnamaldehyde.
Hydrolysis of the dialkylated iminolactones yielded the alpha,alpha-disubstituted alpha-amino acids in good yields and high enantiomeric excesses with good recovery of compound 12.
The use of sodium iodide for the management of bovine respiratory disease
DISEASE Brian MMilllan Shoemake Dr. Brian Vander Ley, Thesis Supervisor ABSTRACT The purpose of this two part project was to determine if (1) beef cattle could secrete iodine into the upper
Hydrogel de dextrine pour applications biomédicales
La presente invention concerne une formulation d'hydrogel de dextrine oxydee reticulee avec du dihydrazide d'acide adipique, qui peut incorporer des polysaccharides, des proteines, des nanogels, des


Bactericidal Activity of MicromolarN-Chlorotaurine: Evidence for Its Antimicrobial Function in the Human Defense System
A significant bactericidal function of N-chlorotaurine and other chloramines during inflammation is suggested, even in the case of a mere attenuation.
Molecular effects of povidone-iodine on relevant microorganisms: an electron-microscopic and biochemical study.
Electron-microscopic and biochemical observations support the conclusion that PVP-I interacts with cell walls of microorganisms causing pore formation or generating solid-liquid interfaces at the lipid membrane level which lead to loss of cytosol material, in addition to enzyme denaturation.
Effect of antithyroid drugs on hydroxyl radical formation and alpha-1-proteinase inhibitor inactivation by neutrophils: therapeutic implications.
These studies indicate that antithyroid drugs are unlikely to prevent cell injury by inhibiting hydroxyl radical generation or by scavengingHydroxyl radicals, but are likely to exert their hepatoprotective anti-inflammatory action by inhibite neutrophil myeloperoxidase, an enzyme akin to thyroid peroxid enzyme.
Investigation on the efficacy of povidone-iodine against antiseptic-resistant species.
PVP-I was confirmed to be a clinically useful antiseptic after it was found that remarkable increases in MICs were seen for CHG and alkyldiaminoethylglycine hydrochloride.
Is there a role of taurine bromamine in inflammation? Interactive effects with nitrite and hydrogen peroxide
TauBr, despite very low concentration of Br− in body fluids, may support TauCl and HOCl in the regulation of inflammatory response and in killing of bacteria by neutrophils.
  • S. Klebanoff
  • Biology
    The Journal of experimental medicine
  • 1967
Iodination of the bacteria by the myeloperoxidase-iodide-H2O2 system was demonstrated chemically and radioautographically and suggests the involvement of labile intermediates of iodide oxidation rather than the more stable end products of oxidation such as iodine.
Taurine chloramine inhibits the production of superoxide anion, IL-6 and IL-8 in activated human polymorphonuclear leukocytes.
It is demonstrated that Tau-Cl down-regulates the production of superoxide anion, IL-6 and IL-8 by activated human PMN, which is a relatively non-toxic and long-lived oxidant.
In vitro Antiseptic Susceptibility of Clinical Isolates from Nosocomial Infections
It is concluded that the turbidity test is a simple and accurate method to evaluate susceptibility to various antiseptics and that it is suitable for a screening of a large number of strains.