Evaluation of agonists and antagonists acting at Group I metabotropic glutamate receptors in the thalamus in vivo.

@article{Salt1999EvaluationOA,
  title={Evaluation of agonists and antagonists acting at Group I metabotropic glutamate receptors in the thalamus in vivo.},
  author={Thomas E. Salt and Jonathan P. Turner and Ann E. Kingston},
  journal={Neuropharmacology},
  year={1999},
  volume={38 10},
  pages={
          1505-10
        }
}
Recordings were made from single neurones in the ventrobasal thalamus of anaesthetised rats in order to evaluate the properties of several agonists and antagonists of Group I mGlu receptors. The selective mGlu1 receptor antagonist LY367385 was found to reduce excitatory responses to iontophoretically applied ACPD and DHPG whereas the mGlu5 agonist CHPG was resistant to antagonism. The antagonists LY367366 and LY393053 reduced responses to all three agonists, but without reducing responses to… CONTINUE READING