Evaluation of adenoviral vascular endothelial growth factor-activated chitosan/hydroxyapatite scaffold for engineering vascularized bone tissue using human osteoblasts: In vitro and in vivo studies.

@article{Ko2014EvaluationOA,
  title={Evaluation of adenoviral vascular endothelial growth factor-activated chitosan/hydroxyapatite scaffold for engineering vascularized bone tissue using human osteoblasts: In vitro and in vivo studies.},
  author={Aysel Koç and Guenter Finkenzeller and Ayşe Eser Elçin and Gerhard Bjoern Stark and Yaşar Murat Elçin},
  journal={Journal of biomaterials applications},
  year={2014},
  volume={29 5},
  pages={748-60}
}
Bone tissue is dependent on an efficient blood supply to ensure delivery of nutrients and oxygen. One method to acquire a vascular-engineered bone tissue could be the use of an angiogenic gene-activated scaffold. In the current study, porous chitosan/hydroxyapatite (C/HA) scaffolds were fabricated via freeze-drying with desired pore size, and then combined with the adenoviral vector encoding vascular endothelial growth factor and green fluorescence protein (Ad-VEGF). Human osteoblasts were… CONTINUE READING

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