Evaluation of acute physiological and molecular alterations in surgically developed hypothyroid Wistar rats

@inproceedings{Patel2013EvaluationOA,
  title={Evaluation of acute physiological and molecular alterations in surgically developed hypothyroid Wistar rats},
  author={Maulik Patel and Vinay Mishra and Vaibhavi Pawar and Ramchandran Ranvir and R. Shyam Sundar and Rajas Dabhi},
  booktitle={Journal of pharmacology & pharmacotherapeutics},
  year={2013}
}
OBJECTIVES To explore the general physiological and molecular changes occurring as a result of acute hypothyroidism. MATERIALS AND METHODS Hypothyroidism was developed by thyroidectomy in wistar rats. After surgery, animals were observed for 14 days in order to determine changes in body weight, feed consumption, rectal temperature, heart rate, and blood pressure, clinical pathological and hormonal alteration. In addition, relative changes in weight, histopathology and MHC - α and β gene… CONTINUE READING