Evaluation of acute hemodynamic effects and pharmacokinetic behaviour of ibopamine in patients with severe heart failure.

@article{Vita1986EvaluationOA,
  title={Evaluation of acute hemodynamic effects and pharmacokinetic behaviour of ibopamine in patients with severe heart failure.},
  author={Cinzia De Vita and E Triulzi and S Devizzi and G. Alvarez Colombo and Marina Palvarini and Felice Pocchiari and R. Pataccini},
  journal={Arzneimittel-Forschung},
  year={1986},
  volume={36 2A},
  pages={349-54}
}
The aim of the present investigation was to evaluate the acute hemodynamic effects of a single oral dose of 200 mg ibopamine (SB-7505), the 3,4-diisobutyryl ester of N-methyldopamine (epinine) in 11 patients with congestive heart failure (CHF) and to compare the influence of dopamine infusion and oral ibopamine on left ventricular function. Free and conjugated epinine plasma levels were also investigated in these patients and in a group of healthy volunteers to evaluate the correlation between… CONTINUE READING