Evaluation of a whole-genome amplification method based on adaptor-ligation PCR of randomly sheared genomic DNA.

@article{Tanabe2003EvaluationOA,
  title={Evaluation of a whole-genome amplification method based on adaptor-ligation PCR of randomly sheared genomic DNA.},
  author={Chikako Tanabe and Kazuhiko Aoyagi and Tokuki Sakiyama and Takashi Kohno and Noriko Yanagitani and Shingo Akimoto and Michiie Sakamoto and Hiromi Sakamoto and Jun Yokota and M. Ohki and Masaaki Terada and Teruhiko Yoshida and Hiroki Sasaki},
  journal={Genes, chromosomes & cancer},
  year={2003},
  volume={38 2},
  pages={168-76}
}
High-throughput genetic studies often require large quantities of DNA for a variety of analyses. Developing and assessing a whole-genome amplification method is thus important, especially with the current desire for large-scale genotyping in previously collected samples for which limited DNA is available. The method we have developed, called PRSG, is based on an adaptor-ligation-mediated PCR of randomly sheared genomic DNA. An unbiased representation was evaluated by performing PCR on 2,607… CONTINUE READING

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