Evaluation of a whole-blood cytokine release assay for use in measuring endotoxin activity of group B Neisseria meningitidis vaccines made from lipid A acylation mutants.

Abstract

Bacterial endotoxin interacts with the human immune system via complex immunological pathways. The evaluation of endotoxicity is important in the development of safe vaccines and immunomodulatory therapeutics. The Limulus amebocyte lysate (LAL) assay is generally accepted by the FDA for use for the quantification of lipopolysaccharide (LPS), while the… (More)
DOI: 10.1128/CVI.00342-09

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@article{Stoddard2010EvaluationOA, title={Evaluation of a whole-blood cytokine release assay for use in measuring endotoxin activity of group B Neisseria meningitidis vaccines made from lipid A acylation mutants.}, author={Mark B. Stoddard and Valerian B. Pinto and Paul B. Keiser and Wendell Zollinger}, journal={Clinical and vaccine immunology : CVI}, year={2010}, volume={17 1}, pages={98-107} }