Evaluation of a transcription-mediated amplification-based HCV and HIV-1 RNA duplex assay for screening individual blood donations: a comparison with a minipool testing system.

@article{Candotti2003EvaluationOA,
  title={Evaluation of a transcription-mediated amplification-based HCV and HIV-1 RNA duplex assay for screening individual blood donations: a comparison with a minipool testing system.},
  author={Daniel Candotti and Aline Richetin and Barbara Cant and Jillian Temple and Cate Sims and Ian Reeves and John J. Barbara and J Y Allain},
  journal={Transfusion},
  year={2003},
  volume={43 2},
  pages={215-25}
}
BACKGROUND NAT was introduced for HCV RNA in 1999 to screen blood donations and improve the safety of the blood supply. STUDY DESIGN AND METHODS The performance of a NAT multiplex for HCV and HIV-1 RNA based on transcription-mediated amplification (TMA) was assessed with various sensitivity panels and by screening 50,000 serologically unscreened, first-time donor plasma samples. Results were compared with a routine NAT screening for HCV RNA by RT-PCR in pools of 96 plasma samples. RESULTS… CONTINUE READING
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