Evaluation of a technetium-99m labeled bombesin homodimer for GRPR imaging in prostate cancer

@article{Yu2012EvaluationOA,
  title={Evaluation of a technetium-99m labeled bombesin homodimer for GRPR imaging in prostate cancer},
  author={Zilin Yu and Giuseppe Carlucci and Hildo J. K. Ananias and Rudi A. J. O. Dierckx and Shuang Liu and Wijnand Helfrich and Fan Wang and Igle Jan de Jong and Philip H. Elsinga},
  journal={Amino Acids},
  year={2012},
  volume={44},
  pages={543-553}
}
Multimerization of peptides can improve the binding characteristics of the tracer by increasing local ligand concentration and decreasing dissociation kinetics. In this study, a new bombesin homodimer was developed based on an ε-aminocaproic acid-bombesin(7–14) (Aca-bombesin(7–14)) fragment, which has been studied for targeting the gastrin-releasing peptide receptor (GRPR) in prostate cancer. The bombesin homodimer was conjugated to 6-hydrazinopyridine-3-carboxylic acid (HYNIC) and labeled with… CONTINUE READING