Evaluation of a recombinant yeast cell estrogen screening assay.

  title={Evaluation of a recombinant yeast cell estrogen screening assay.},
  author={Nicholas Coldham and Manjeet Dave and Susila Sivapathasundaram and Donald P McDonnell and Carol Connor and Maurice J. Sauer},
  journal={Environmental Health Perspectives},
  pages={734 - 742}
A wide range of chemicals with diverse structures derived from plant and environmental origins are reported to have hormonal activity. The potential for appreciable exposure of humans to such substances prompts the need to develop sensitive screening methods to quantitate and evaluate the risk to the public. Yeast cells transformed with plasmids encoding the human estrogen receptor and an estrogen responsive promoter linked to a reporter gene were evaluated for screening compounds for… CONTINUE READING