Evaluation of a proposed in vitro test strategy using neuronal and non-neuronal cell systems for detecting neurotoxicity.

@article{Gartlon2006EvaluationOA,
  title={Evaluation of a proposed in vitro test strategy using neuronal and non-neuronal cell systems for detecting neurotoxicity.},
  author={Joanne Gartlon and Agnieszka Kinsner and Anna Bal-Price and Sandra Coecke and Richard H Clothier},
  journal={Toxicology in vitro : an international journal published in association with BIBRA},
  year={2006},
  volume={20 8},
  pages={1569-81}
}
The European Commission White Paper, "Strategy for a future chemicals policy" (EC, 2001) is estimated to require the testing of approximately 30,000 "existing" chemicals by 2012. Recommended in vitro tests require validation. As the White Paper (EC, 2001) requires neurotoxic data, this study evaluated an in vitro testing strategy for predicting in vivo neurotoxicity. The sensitivities of differentiated PC12 cells and primary cerebellum granule cells (CGC) were compared to undifferentiated PC12… CONTINUE READING

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