Evaluation of a potential epigenetic biomarker by quantitative methyl‐single nucleotide polymorphism analysis

  title={Evaluation of a potential epigenetic biomarker by quantitative methyl‐single nucleotide polymorphism analysis},
  author={Karen Uhlmann and Anja Brinckmann and Mohammad Reza Toliat and Heide Ritter and Peter J. N{\"u}rnberg},
Tumorigenesis is characterized by alterations of methylation profiles including loss and gain of 5‐methylcytosine. Recently, we identified a single CpG, which seemed to be consistently hypomethylated in pilocytic astrocytomas but not in other gliomas. To evaluate its applicability as a biomarker, we examined its methylation status in a large panel of gliomas (n = 97). Methylation‐dependent DNA sequence variation may be considered a kind of single nucleotide polymorphism (methylSNP). MethylSNPs… 

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