Evaluation of a poliovirus-binding inhibition assay as an alternative to the virus neutralization test.

@article{Herremans1997EvaluationOA,
  title={Evaluation of a poliovirus-binding inhibition assay as an alternative to the virus neutralization test.},
  author={M M P Tineke Herremans and Johan H. J. Reimerink and A Ras and Harrie G A M van der Avoort and Tjeerd G. Kimman and Anton M. van Loon and Marina A E Conyn-van Spaendonck and Marion P. G. Koopmans},
  journal={Clinical and diagnostic laboratory immunology},
  year={1997},
  volume={4 6},
  pages={659-64}
}
An enzyme-linked immunosorbent assay (ELISA)-based poliovirus-binding inhibition (PoBI) test to detect and quantify antibodies to polioviruses was optimized and evaluated for use in population studies as an alternative to the virus neutralization test (NT) in tissue culture. The sensitivities of the inhibition ELISA compared with the NT in an inactivated poliovirus vaccine (IPV)-vaccinated population were 98.6, 97.4, and 92.1% for serotypes 1, 2, and 3, respectively. The specificities of the… CONTINUE READING

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