Evaluation of a perforated drug delivery system in mice for prolonged and constant release of a hydrophilic drug

Abstract

A drug delivery system (DDS) consisting of a perforated microtube (polyimide, inside diameter = 1.8 mm, tube length = 20 mm, hole size = 0.15 mm) was characterized in vitro and in vivo for its usefulness for long-term release of hydrophilic drugs at a constant rate. Sodium fluorescein mixed with stearic acid was used as the model drug. The DDS was packed… (More)
DOI: 10.1007/s13346-012-0062-6

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