Evaluation of a novel placental alpha microglobulin-1 (PAMG-1) test to predict spontaneous preterm delivery

@article{Nikolova2014EvaluationOA,
  title={Evaluation of a novel placental alpha microglobulin-1 (PAMG-1) test to predict spontaneous preterm delivery},
  author={Tanja Nikolova and Oleg R Bayev and Natasha Nikolova and Gian Carlo Di Renzo},
  journal={Journal of Perinatal Medicine},
  year={2014},
  volume={42},
  pages={473 - 477}
}
Abstract Objective: The PartoSure™ time-to-delivery (TTD) test (AmniSure International, Boston, MA, USA) is a newly available bedside test for the prediction of time to spontaneous preterm delivery via the detection of placental alpha microglobulin-1. The objective of this study was to determine the efficacy of the test in predicting imminent delivery in 7 or 14 days from the time of testing. Methods: The study population consisted of 101 consecutively recruited pregnant women with singleton… Expand
Comparison of a novel test for placental alpha microglobulin-1 with fetal fibronectin and cervical length measurement for the prediction of imminent spontaneous preterm delivery in patients with threatened preterm labor
TLDR
PAMG-1 detection by PartoSure is the single best predictor of imminent spontaneous delivery within 7 days compared to fFN and CL, and has the greatest clinical utility in patients with CL between 15 and 35 mm. Expand
Evaluation of placental alpha microglobulin-1(PAMG1) accuracy for prediction of preterm delivery in women with the symptoms of spontaneous preterm labor; a comparison with cervical length and number of contractions.
  • M. Kashanian, Nooshin Eshraghi, M. Rahimi, N. Sheikhansari
  • Medicine
  • The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
  • 2020
TLDR
Evaluated the accuracy of the placental alpha microglobulin-1 (PAMG-1) test for identifying women who referred to hospitals with signs of spontaneous preterm labor and ultimately delivered within ≤48 h and ≤7 of testing and ≤37 weeks of gestation and its comparison with cervical length of <25 mm and number of contractions. Expand
Placental Alpha Microglobulin-1 Compared With Fetal Fibronectin to Predict Preterm Delivery in Symptomatic Women.
TLDR
Although placental α microglobulin-1 performed the same as fetal fibronectin in ruling out spontaneous preterm delivery among symptomatic women, it demonstrated statistical superiority in predicting it. Expand
Placental alpha microglobulin-1 (PartoSure) test for the prediction of preterm birth: a systematic review and meta-analysis
  • R. Pirjani, A. Moini, +4 authors M. Sepidarkish
  • Medicine
  • The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
  • 2019
TLDR
Cervical PAMG-1 had a high accuracy to predict preterm birth within 7 and 14 d of testing in symptomatic pregnant women. Expand
Comparison of PAMG-1 and phIGFBP-1 Tests for the Prediction of Preterm Delivery in Patients with Preterm Labor
TLDR
This study strongly suggests that the PAMG-1 test is more accurate for predicting imminent spontaneous preterm delivery as compared to phIGFBP-1, and can significantly reduce economic burden caused by unnecessary admission and treatment of patients suspected of preterm labor. Expand
Evaluation of the quantitative fetal fibronectin test and PAMG-1 test for the prediction of spontaneous preterm birth in patients with signs and symptoms suggestive of preterm labor
  • M. Ravi, Mercy Beljorie, Karim Medhat El Masry
  • Medicine
  • The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
  • 2018
TLDR
Compared with qfFN, the PAMG-1 test is a better predictor of spontaneous delivery within 7 d while maintaining a very high negative predictive value, and is an easy-to-use bedside test that provides rapid results. Expand
Methods of detection and prevention of preterm labour and the PAMG-1 detection test: a review
TLDR
The use of PAMG-1 may make it possible to target the women at risk with a shortened cervix on ultrasound those with an imminent preterm delivery and therefore to adapt management, especially the administration of antenatal corticosteroid therapy. Expand
Use of cervicovaginal PAMG-1 protein as a predictor of delivery within seven days in pregnancies at risk of premature birth
TLDR
The diagnostic accuracy of PAMG-1 is similar to that of fFN in terms of preterm labour detection within 7 days in pregnancies at risk of premature birth. Expand
The value of a vaginal sample for detecting PAMG-1 (Partosure®) in women with a threatened preterm delivery (the MAPOSURE Study): protocol for a multicenter prospective study
TLDR
This study assesses the diagnostic performance of the test to detect the placental alpha microglobulin 1 (PAMG-1) for the prediction of delivery within 7 days in women with TPD and examines the sensitivity, PPV, and NPV of the Partosure® test and the factors associated with false positives. Expand
Comparison of the effectiveness of a PAMG-1 test and standard clinical assessment in the prediction of preterm birth and reduction of unnecessary hospital admissions
  • Ghassan Lotfi, Saima Faraz, +5 authors Abeer Ammar
  • Medicine
  • The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
  • 2019
TLDR
The PAMG-1 test was found to be statistically superior to standard clinical assessment alone, with respect to specificity, and could reduce up to 91% of unnecessary admissions for women presenting with threatened preterm labor. Expand
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