Evaluation of a novel immunogenic vaccine platform based on a genome replication-deficient Sendai vector.

@article{Wiegand2013EvaluationOA,
  title={Evaluation of a novel immunogenic vaccine platform based on a genome replication-deficient Sendai vector.},
  author={Marian Alexander Wiegand and Gianni Gori-Savellini and Barbara Martorelli and Sascha Bossow and W. J. Neubert and Maria Grazia Cusi},
  journal={Vaccine},
  year={2013},
  volume={31 37},
  pages={
          3888-93
        }
}
We developed a novel vaccine platform based on a paramyxoviral, genome replication-deficient Sendai virus vector that can express heterologous genes inserted into the genome. To validate the novel approach in vivo, we generated a combined vaccine candidate against human respiratory syncytial virus (RSV) and human parainfluenza virus type 3 (PIV3). The present study compares two different methods of displaying heterologous antigens: (i) the RSV fusion (F) protein, encoded as a secretable version… CONTINUE READING

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