Evaluation of a novel dry eye model induced by oral administration of finasteride

@inproceedings{Li2017EvaluationOA,
  title={Evaluation of a novel dry eye model induced by oral administration of finasteride},
  author={Kai Li and Chuanwei Zhang and Zichao Yang and Yuliang Wang and Haipeng Si},
  booktitle={Molecular medicine reports},
  year={2017}
}
Dry eye is a common eye disease, and suitable animal models are indispensable for investigating the pathogenesis and developing treatments for dry eye. The present study was conducted to develop an androgen deficiency dry eye model induced by finasteride, and to evaluate ocular surface status and inflammatory cytokine gene expression in the lacrimal gland using a cytokine antibody array system. The results revealed that the antiandrogenic drug finasteride induced significant tear deficiency… CONTINUE READING
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