Evaluation of a new tool for exploring podocyte biology: mouse Nphs1 5' flanking region drives LacZ expression in podocytes.

@article{Mller2000EvaluationOA,
  title={Evaluation of a new tool for exploring podocyte biology: mouse Nphs1 5' flanking region drives LacZ expression in podocytes.},
  author={Marcus M{\"o}ller and Iulia A. Kovari and Lawrence B. Holzman},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2000},
  volume={11 12},
  pages={2306-14}
}
Study of podocyte biology has been hampered by limitations in available experimental models that both recapitulate the in vivo phenotypes of this cell and can be readily and specifically manipulated at the molecular level. Transgenic manipulation of the podocyte represents one approach that might circumvent these limitations. The purpose of this study was to identify a promoter-enhancer that would direct the expression of transgenes in a podocyte-specific manner. The nephrin (Nphs1) promoter… CONTINUE READING

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