Evaluation of a new beta-adrenergic blocking agent, carteolol, based on metabolic responses in rats-II. Blockade by carteolol of the epinephrine-and isoproterenol-induced increases of tissue and blood cyclic AMP in vivo.

@article{Saitoh1976EvaluationOA,
  title={Evaluation of a new beta-adrenergic blocking agent, carteolol, based on metabolic responses in rats-II. Blockade by carteolol of the epinephrine-and isoproterenol-induced increases of tissue and blood cyclic AMP in vivo.},
  author={Yuichi Saitoh and Seiji Morita and Yasuo Irie and Hideaki Kohri},
  journal={Biochemical pharmacology},
  year={1976},
  volume={25 16},
  pages={
          1843-9
        }
}
View on PubMed
doi.org
23 Citations
Background Citations
1

23 Citations

Effect of a selective β2-adrenoceptor agonist, procaterol, on tissue cyclic AMP level: Its determination after tissue fixation by microwave irradiation

Age-related changes of in vivo β-adrenergic responsiveness in normotensive and spontaneously hypertensive rats

Effects of cardiotoxic doses of adrenergic amines on myocardial cyclic AMP.

Evaluation of a new beta-adrenoceptor agonist, procaterol, based on metabolic responses in rats.

The plasma cyclic AMP response to catecholamines as potentiated by phentolamine in rats.

Increases in plasma cyclic AMP dependent on endogenous catecholamines.

Adrenomedullary and β-adrenergic participation in enhanced sympathetic pressor responses of spontaneously hypertensive rats

Effect of chlorpromazine on plasma adenosine 3',5'-cyclic phosphate level.

Effect of narcotic analgesics on plasma cyclic AMP levels in male mice

Plasma cyclic AMP in the morphine-tolerant rat.

References

SHOWING 1-10 OF 62 REFERENCES

Evaluation of a new beta-adrenergic blocking agent, carteolol, based on metabolic responses in rats-I. Blockade in vivo of epinephrine- and isoproterenol-induced alterations of blood concentrations of carbohydrate and lipid intermediary metabolites.

Effects of catecholamines and adrenergic-blocking agents on plasma and urinary cyclic nucleotides in man.

The data suggest the possibility that cyclic GMP metabolism is responsive either to alpha-adrenergic stimulation or to parasympathetic stimulation which occurs as a reflexive consequence of the pressor effect of alpha- adrenergic agents.

Effects of adrenergic agents on carbohydrate metabolism of rat liver: activities of adenyl cyclase and glycogen phosphorylase.

The findings suggest that the adnenergic metabolic receptor in rat liver is similar in its response to agonists and antagonists to those receptors in other tissues which have been classified as beta receptors and that previous reports of the ineffectiveness of I in the rat resulted from its apparent autoinhibitory effect on the hepatic receptor of this species.

Characterization of the adrenergic receptors mediating a rise in cyclic 3'-5'-adenosine monophosphate in rat cerebral cortex.

  • J. PerkinsM. Moore
  • Biology, Chemistry
    The Journal of pharmacology and experimental therapeutics
  • 1973
The results suggest that NE interacts with at least two types of receptors (analogous to alpha and beta ) whereas ISO appears to react with a single type (analagous to beta ).

Cardiovascular studies of 5-(3-tert-butylamino-2-hydroxy) propoxy-3,4-dihydrocarbostyril hydrochloride (OPC-1085), a new potent beta-adrenergic blocking agent.

OPC-1085 showed almost the same beta-adrenergic blocking potency as pindolol, but was approximately 30 and 20 times stronger than propranolol against isoproterenol and cardiac nerve stimulation, respectively.

Inhibition of glucagon-mediated increases in hepatic cyclic adenosine 3', 5'-monophosphate by prostaglandin E1 and E2.

PGE partially inhibited glucagon-mediated alterations in both hepatic cAMP and in glycogen synthetase activity, and in hepatic homogenates, maximal doses of PGE, enhanced basal adenosine 3',5'-monophosphate activity.

Regulation of cyclic adenosine 3',5'-monophosphate levels in guinea-pig cerebral cortex by interaction of alpha adrenergic and adenosine receptor activity.

Direct assay of adenosine 3',5'-monophosphate in guinea-pig cerebral cortex in vitro has shown that an alpha adrenergic receptor that was previously found to increase tissue content of cyclic AMP requires the co-presence ofadenosine, which argues against indirect mediation of the alpha receptor effect via the release of K+ or via an unknown neurohumoral agent.

Cyclic nucleotide levels in incubations of guinea pig trachea.

CHARACTERISTICS OF THE CATECHOLAMINE AND HISTAMINE RECEPTOR SITES MEDIATING ACCUMULATION OF CYCLIC ADENOSINE 3′,5′‐MONOPHOSPHATE IN GUINEA PIG BRAIN 1

Only antihistaminic agents were capable of antagonizing the histamine‐induced increase of both [3H]‐ and total cyclic AMP in these two brain areas.

Effect of Glucagon on the Level of Adenosine 3',5'-Monophosphate in Rat Liver and Adipose Tissue: Dependence on the Route of Administration

In animals which had been fasted for 18 hr prior to the injection of glucagon, sc injections gave a greater, more prolonged, and less variable elevation of hepatic c-AMP levels than did the ip injections.
...