Evaluation of a new beta-adrenergic blocking agent, carteolol, based on metabolic responses in rats-II. Blockade by carteolol of the epinephrine-and isoproterenol-induced increases of tissue and blood cyclic AMP in vivo.

@article{Saitoh1976EvaluationOA,
  title={Evaluation of a new beta-adrenergic blocking agent, carteolol, based on metabolic responses in rats-II. Blockade by carteolol of the epinephrine-and isoproterenol-induced increases of tissue and blood cyclic AMP in vivo.},
  author={Yuichi Saitoh and Seiji Morita and Yasuo Irie and Hideaki Kohri},
  journal={Biochemical pharmacology},
  year={1976},
  volume={25 16},
  pages={
          1843-9
        }
}

Effects of cardiotoxic doses of adrenergic amines on myocardial cyclic AMP.

Plasma cyclic AMP in the morphine-tolerant rat.

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The data suggest the possibility that cyclic GMP metabolism is responsive either to alpha-adrenergic stimulation or to parasympathetic stimulation which occurs as a reflexive consequence of the pressor effect of alpha- adrenergic agents.

Effects of adrenergic agents on carbohydrate metabolism of rat liver: activities of adenyl cyclase and glycogen phosphorylase.

The findings suggest that the adnenergic metabolic receptor in rat liver is similar in its response to agonists and antagonists to those receptors in other tissues which have been classified as beta receptors and that previous reports of the ineffectiveness of I in the rat resulted from its apparent autoinhibitory effect on the hepatic receptor of this species.

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The results suggest that NE interacts with at least two types of receptors (analogous to alpha and beta ) whereas ISO appears to react with a single type (analagous to beta ).

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OPC-1085 showed almost the same beta-adrenergic blocking potency as pindolol, but was approximately 30 and 20 times stronger than propranolol against isoproterenol and cardiac nerve stimulation, respectively.

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Direct assay of adenosine 3',5'-monophosphate in guinea-pig cerebral cortex in vitro has shown that an alpha adrenergic receptor that was previously found to increase tissue content of cyclic AMP requires the co-presence ofadenosine, which argues against indirect mediation of the alpha receptor effect via the release of K+ or via an unknown neurohumoral agent.

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CHARACTERISTICS OF THE CATECHOLAMINE AND HISTAMINE RECEPTOR SITES MEDIATING ACCUMULATION OF CYCLIC ADENOSINE 3′,5′‐MONOPHOSPHATE IN GUINEA PIG BRAIN 1

Only antihistaminic agents were capable of antagonizing the histamine‐induced increase of both [3H]‐ and total cyclic AMP in these two brain areas.

Effect of Glucagon on the Level of Adenosine 3',5'-Monophosphate in Rat Liver and Adipose Tissue: Dependence on the Route of Administration

In animals which had been fasted for 18 hr prior to the injection of glucagon, sc injections gave a greater, more prolonged, and less variable elevation of hepatic c-AMP levels than did the ip injections.
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