Evaluation of a new beta-adrenergic blocking agent, carteolol, based on metabolic responses in rats-II. Blockade by carteolol of the epinephrine-and isoproterenol-induced increases of tissue and blood cyclic AMP in vivo.
@article{Saitoh1976EvaluationOA, title={Evaluation of a new beta-adrenergic blocking agent, carteolol, based on metabolic responses in rats-II. Blockade by carteolol of the epinephrine-and isoproterenol-induced increases of tissue and blood cyclic AMP in vivo.}, author={Yuichi Saitoh and Seiji Morita and Yasuo Irie and Hideaki Kohri}, journal={Biochemical pharmacology}, year={1976}, volume={25 16}, pages={ 1843-9 } }
23 Citations
Effect of a selective β2-adrenoceptor agonist, procaterol, on tissue cyclic AMP level: Its determination after tissue fixation by microwave irradiation
- Biology, Medicine
- 1979
Age-related changes of in vivo β-adrenergic responsiveness in normotensive and spontaneously hypertensive rats
- Medicine, Biology
- 1984
Effects of cardiotoxic doses of adrenergic amines on myocardial cyclic AMP.
- Biology, ChemistryJournal of molecular and cellular cardiology
- 1978
Evaluation of a new beta-adrenoceptor agonist, procaterol, based on metabolic responses in rats.
- Biology, ChemistryBiochemical pharmacology
- 1978
The plasma cyclic AMP response to catecholamines as potentiated by phentolamine in rats.
- Biology, ChemistryEuropean journal of pharmacology
- 1978
Increases in plasma cyclic AMP dependent on endogenous catecholamines.
- BiologyEuropean journal of pharmacology
- 1978
Adrenomedullary and β-adrenergic participation in enhanced sympathetic pressor responses of spontaneously hypertensive rats
- Biology, Medicine
- 1987
Plasma cyclic GMP: response to cholinergic agents.
- Biology, ChemistryEuropean journal of pharmacology
- 1978
The tissue content of cyclic AMP in rats after microwave irradiation in vivo.
- Biology, MedicineJournal of pharmacobio-dynamics
- 1980
It is concluded that rapid tissue fixation by microwave irradiation may provide a useful means for obtaining reliable values of the tissue cyclic AMP content.
References
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Evaluation of a new beta-adrenergic blocking agent, carteolol, based on metabolic responses in rats-I. Blockade in vivo of epinephrine- and isoproterenol-induced alterations of blood concentrations of carbohydrate and lipid intermediary metabolites.
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- 1976
Regulation by beta-adrenergic receptor and muscarinic cholinergic receptor activation of intracellular cyclic AMP and cyclic GMP levels in rat lung slices.
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Effects of catecholamines and adrenergic-blocking agents on plasma and urinary cyclic nucleotides in man.
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- 1972
The data suggest the possibility that cyclic GMP metabolism is responsive either to alpha-adrenergic stimulation or to parasympathetic stimulation which occurs as a reflexive consequence of the pressor effect of alpha- adrenergic agents.
Effects of adrenergic agents on carbohydrate metabolism of rat liver: activities of adenyl cyclase and glycogen phosphorylase.
- Biology, ChemistryThe Journal of pharmacology and experimental therapeutics
- 1972
The findings suggest that the adnenergic metabolic receptor in rat liver is similar in its response to agonists and antagonists to those receptors in other tissues which have been classified as beta receptors and that previous reports of the ineffectiveness of I in the rat resulted from its apparent autoinhibitory effect on the hepatic receptor of this species.
Characterization of the adrenergic receptors mediating a rise in cyclic 3'-5'-adenosine monophosphate in rat cerebral cortex.
- Biology, ChemistryThe Journal of pharmacology and experimental therapeutics
- 1973
The results suggest that NE interacts with at least two types of receptors (analogous to alpha and beta ) whereas ISO appears to react with a single type (analagous to beta ).
Cardiovascular studies of 5-(3-tert-butylamino-2-hydroxy) propoxy-3,4-dihydrocarbostyril hydrochloride (OPC-1085), a new potent beta-adrenergic blocking agent.
- Biology, ChemistryJapanese journal of pharmacology
- 1974
OPC-1085 showed almost the same beta-adrenergic blocking potency as pindolol, but was approximately 30 and 20 times stronger than propranolol against isoproterenol and cardiac nerve stimulation, respectively.
Inhibition of glucagon-mediated increases in hepatic cyclic adenosine 3', 5'-monophosphate by prostaglandin E1 and E2.
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- 1974
PGE partially inhibited glucagon-mediated alterations in both hepatic cAMP and in glycogen synthetase activity, and in hepatic homogenates, maximal doses of PGE, enhanced basal adenosine 3',5'-monophosphate activity.
Regulation of cyclic adenosine 3',5'-monophosphate levels in guinea-pig cerebral cortex by interaction of alpha adrenergic and adenosine receptor activity.
- BiologyThe Journal of pharmacology and experimental therapeutics
- 1975
Direct assay of adenosine 3',5'-monophosphate in guinea-pig cerebral cortex in vitro has shown that an alpha adrenergic receptor that was previously found to increase tissue content of cyclic AMP requires the co-presence ofadenosine, which argues against indirect mediation of the alpha receptor effect via the release of K+ or via an unknown neurohumoral agent.
Cyclic nucleotide levels in incubations of guinea pig trachea.
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- 1974
CHARACTERISTICS OF THE CATECHOLAMINE AND HISTAMINE RECEPTOR SITES MEDIATING ACCUMULATION OF CYCLIC ADENOSINE 3′,5′‐MONOPHOSPHATE IN GUINEA PIG BRAIN 1
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- 1973
Only antihistaminic agents were capable of antagonizing the histamine‐induced increase of both [3H]‐ and total cyclic AMP in these two brain areas.