Evaluation of a formalin-inactivated Rift Valley fever vaccine in sheep.

@article{Harrington1980EvaluationOA,
  title={Evaluation of a formalin-inactivated Rift Valley fever vaccine in sheep.},
  author={Dana Harrington and H W Lupton and C L Crabbs and Clarence J. Peters and Justin Reynolds and Tracy Slone},
  journal={American journal of veterinary research},
  year={1980},
  volume={41 10},
  pages={1559-64}
}
A formalin-inactivated Rift Valley fever (RVF) vaccine prepared in cell culture for human use was immunogenic in sheep. Vaccine was administered as a single dose of diluted (1:5) or undiluted vaccine with or without an adjuvant. Serum-neutralizing antibodies induced by RVF vaccine persisted for at least 7 months. Seven of 11 vaccinated sheep with prechallenge plaque-reduction neutralization (PRN80) antibody titers of less than or equal to 10 were protected against challenge exposure with 10(6… CONTINUE READING
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