Evaluation of a dithiocarbamate derivative as an inhibitor of human glutaredoxin-1.

@article{Sadhu2013EvaluationOA,
  title={Evaluation of a dithiocarbamate derivative as an inhibitor of human glutaredoxin-1.},
  author={Satya S. Sadhu and Eduardo Callegari and Yong Zhao and Xiangming Guan and Teresa M Seefeldt},
  journal={Journal of enzyme inhibition and medicinal chemistry},
  year={2013},
  volume={28 3},
  pages={456-62}
}
CONTEXT Glutaredoxins (GRX) are involved in the regulation of thiol redox state. GRX-1 is a cytosolic enzyme responsible for the catalysis of deglutathionylation of proteins. To date, very few inhibitors of GRX-1 have been reported. OBJECTIVE The objective of this paper is to report 2-acetylamino-3-[4-(2-acetylamino-2-carboxyethyl… CONTINUE READING