Evaluation of a conjugate of purified antibodies against human AFP-dextran-daunorubicin to human AFP-producing yolk sac tumor cell lines

@article{Ohkawa1986EvaluationOA,
  title={Evaluation of a conjugate of purified antibodies against human AFP-dextran-daunorubicin to human AFP-producing yolk sac tumor cell lines},
  author={Kiyoshi Ohkawa and Nozomu Hibi and Yutaka Tsukada},
  journal={Cancer Immunology, Immunotherapy},
  year={1986},
  volume={22},
  pages={81-86}
}
The anticancer drug, DNR, was conjugated to an affinity-purified horse antibody to human AFP (aAFP) via a dextran bridge. The conjugate (immunoglobulin: DNR molar ratio, 1:50) was twice as potent as free DNR in an in vitro cytotoxicity assay against an AFP-producing human yolk sac tumor. The in vivo effect of aAFP, DNR, and the conjugate was tested against… CONTINUE READING