This study evaluated the use of a computerized patient profile combined with a reminder system to increase refill compliance of patients on cardiovascular medications. There were 311 patients randomly assigned into one of three groups. Patients in group 1 were monitored for refill compliance only. Group 2 patients received a postcard reminder; group 3 patients received a telephone call reminder. Refill compliance was monitored via the computerized patient profile system for a period of three months. Data collection included refill compliance, reasons for noncompliance, and the number of prescription medications for each patient. There was a significant difference between the overall mean rate of compliance between the control and intervention groups. An increase in refill compliance for all groups occurred over three months. There was no significant difference in compliance between the treatment groups. Overall, the medication reminder system appeared to be effective; however, modifications in the system should be pursued.