Evaluation of a complementarity-determining region-grafted (humanized) anti-carcinoembryonic antigen monoclonal antibody in preclinical and clinical studies.

@article{Sharkey1995EvaluationOA,
  title={Evaluation of a complementarity-determining region-grafted (humanized) anti-carcinoembryonic antigen monoclonal antibody in preclinical and clinical studies.},
  author={Robert M Sharkey and Malik Juweid and Jerry Shevitz and T. M. Behr and Robert M. Dunn and Lawrence C. Swayne and Gilbert Y. Wong and Rosalyn D. Blumenthal and Gary L. Griffiths and Jeffry A. Siegel},
  journal={Cancer research},
  year={1995},
  volume={55 23 Suppl},
  pages={5935s-5945s}
}
A complementarity-determining region-grafted (humanized) version of MN-14 (hMN-14), a high-affinity, anti-carcinoembryonic antigen (CEA) murine monoclonal antibody (mMAb), was selected from several clones that differed slightly in their framework composition. One clone was selected based on its similar binding affinity to CEA as that observed with mMN-14 MAb and its production yields. Targeting studies, using 131I-labeled humanized MN-14 (hMN-14)/125I-labeled mMN-14 IgG in GW-39 tumor-bearing… CONTINUE READING

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