Evaluation of a Yersinia pestis mutant impaired in a thermoregulated type VI-like secretion system in flea, macrophage and murine models.

@article{Robinson2009EvaluationOA,
  title={Evaluation of a Yersinia pestis mutant impaired in a thermoregulated type VI-like secretion system in flea, macrophage and murine models.},
  author={Jennilee B Robinson and Maxim V Telepnev and Irina V Zudina and Donald H. Bouyer and John A. Montenieri and Scott W. Bearden and Kenneth L. Gage and Stacy L. Agar and Sheri M. Foltz and Sadhana Chauhan and Ashok Kumar Chopra and Vladimir L. Motin},
  journal={Microbial pathogenesis},
  year={2009},
  volume={47 5},
  pages={243-51}
}
Type VI secretion systems (T6SSs) have been identified recently in several Gram-negative organisms and have been shown to be associated with virulence in some bacterial pathogens. A T6SS of Yersinia pestis CO92 (locus YPO0499-YPO0516) was deleted followed by investigation of the phenotype of this mutation. We observed that this T6SS locus of Y. pestis was preferentially expressed at 26 degrees C in comparison to 37 degrees C suggesting a possible role in the flea cycle. However, we found that… CONTINUE READING

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