Evaluation of a Potential Tigecycline‐Warfarin Drug Interaction

@article{Zimmerman2008EvaluationOA,
  title={Evaluation of a Potential Tigecycline‐Warfarin Drug Interaction},
  author={James J. Zimmerman and Donald G. Raible and Dawn Harper and Kyle T. Matschke and John L. Speth},
  journal={Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy},
  year={2008},
  volume={28}
}
Study Objective. To evaluate the potential for a clinically significant drug interaction between tigecycline and warfarin by using pharmacokinetic and anticoagulant assessments. 

Phase 1 Study of the Effect of Icosapent Ethyl on Warfarin Pharmacokinetic and Anticoagulation Parameters

Co-administration of these drugs was safe and well tolerated in this study of healthy adult subjects and IPE 4 g/day did not significantly change the single-dose AUC0–∞ or Cmax of R- and S-warfarin or the anticoagulation pharmacodynamics of warfarin when co-administered as racemic Warfarin at 25 mg.

Review of Tigecycline: Focus on Clinical Utilization

The antimicrobial profile and available clinical data for the first member of the glycylcycline class, tigecycline, may provide a therapeutic option in select patients, given its broad spectrum of activity, including multi-drug resistant (MDR) strains.

Tigecycline: a critical safety review

The safety profile of tigecycline, a broad spectrum antibiotic covering against many MDR organisms, is reviewed, including its side effects and drug interactions.

Beware of drug interaction between tigecycline and tacrolimus

A case of marked elevation in tacrolimus concentration after use of tigecycline in a renal transplant recipient in a patient with a background of diabetic kidney disease is reported, and similar observation has been reported in another renal transplants recipient, accompanied by resolution of hyperkalaemia.

A review of tigecycline--the first glycylcycline.

  • L. Peterson
  • Medicine, Biology
    International journal of antimicrobial agents
  • 2008

Influence of ORM1 polymorphisms on the maintenance stable warfarin dosage

ORM1 is identified as another polymorphic gene affecting warfarin dose requirements, and ORM1 *S carriers require lower maintenance doses to achieve and maintain an optimal level of anticoagulation.

Tigecycline antibacterial activity, clinical effectiveness, and mechanisms and epidemiology of resistance: narrative review

  • S. YaghoubiA. Zekiy Farajolah Maleki
  • Medicine, Biology
    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
  • 2021
Tigecycline showed in vitro susceptibility to Coxiella spp, Rickettsia spp.

The Development of Third-Generation Tetracycline Antibiotics and New Perspectives

The tetracycline antibiotic class has acquired new valuable members due to the optimisation of the chemical structure, and new derivatives are developed and studied primarily for the antibiotic effect and other biological effects.

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