Evaluation of a Potential Tigecycline‐Warfarin Drug Interaction

@article{Zimmerman2008EvaluationOA,
  title={Evaluation of a Potential Tigecycline‐Warfarin Drug Interaction},
  author={James J. Zimmerman and Donald G. Raible and Dawn Harper and Kyle T. Matschke and John L. Speth},
  journal={Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy},
  year={2008},
  volume={28}
}
Study Objective. To evaluate the potential for a clinically significant drug interaction between tigecycline and warfarin by using pharmacokinetic and anticoagulant assessments. 
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  • Medicine
  • International journal of antimicrobial agents
  • 2008
TLDR
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Evaluating the effects of fimasartan on the pharmacodynamics and pharmacokinetics of warfarin in healthy volunteers to meet regulatory requirements for drug marketing and labeling in Korea found multiple doses did not seem to alter the pharmacodynamic or pharmacokinetic parameters. Expand
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ORM1 is identified as another polymorphic gene affecting warfarin dose requirements, and ORM1 *S carriers require lower maintenance doses to achieve and maintain an optimal level of anticoagulation. Expand
Review of macrolides (azithromycin, clarithromycin), ketolids (telithromycin) and glycylcyclines (tigecycline).
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Tigecycline antibacterial activity, clinical effectiveness, and mechanisms and epidemiology of resistance: narrative review
  • S. Yaghoubi, A. Zekiy, +5 authors Farajolah Maleki
  • Medicine
  • European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
  • 2021
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Tigecycline showed in vitro susceptibility to Coxiella spp, Rickettsia spp. Expand
Severe coagulation disorder with hypofibrinogenemia associated with the use of tigecycline
TLDR
These changes are in line with a severe coagulation disturbance, which has also some of the characteristics of disseminated intravascular coagulations, a condition which might develop in a patient with severe peritonitis while signs of inflammation improved. Expand
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