Evaluation of a Group A Streptococcus synthetic oligosaccharide as vaccine candidate.

@article{Kabanova2010EvaluationOA,
  title={Evaluation of a Group A Streptococcus synthetic oligosaccharide as vaccine candidate.},
  author={Anna Kabanova and Immaculada Margarit and Francesco Berti and Maria Rosaria Romano and Guido Grandi and Giuliano Bensi and Emiliano Chiarot and Daniela Proietti and Erwin Frans Swennen and Emilia Cappelletti and Paola Fontani and Daniele Casini and Roberto Adamo and Vittoria Pinto and David O. F. Skibinski and Sabrina Capo and Giada Buffi and Marilena Gallotta and William J. Christ and Aaron S. Campbell and Elizabeth Shapiro Pena and Peter H Seeberger and Rino Rappuoli and Paolo Costantino},
  journal={Vaccine},
  year={2010},
  volume={29 1},
  pages={
          104-14
        }
}
Bacterial infections caused by Group A Streptococcus (GAS) are a serious health care concern that currently cannot be prevented by vaccination. The GAS cell-wall polysaccharide (GAS-PS) is an attractive vaccine candidate due to its constant expression pattern on different bacterial strains and protective properties of anti-GAS-PS antibodies. Here we report for the first time the immunoprotective efficacy of glycoconjugates with synthetic GAS oligosaccharides as compared to those containing the… CONTINUE READING
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