Evaluation of a Digene-recommended algorithm for human papillomavirus low-positive results present in a "retest zone".

@article{Muldrew2007EvaluationOA,
  title={Evaluation of a Digene-recommended algorithm for human papillomavirus low-positive results present in a "retest zone".},
  author={Kenneth L. Muldrew and Safedin H Beqaj and Jian Han and Shanjuan H Lum and V. Clinard and Stephen J Schultenover and Y Tang},
  journal={American journal of clinical pathology},
  year={2007},
  volume={127 1},
  pages={
          97-102
        }
}
The Digene Hybrid Capture 2 (hc2) high-risk human papillomavirus (HPV) DNA test (Digene, Gaithersburg, MD) is widely used for triage of women with atypical squamous cells of undetermined significance. Results in a "retest zone" (weakly positive tests) are repeated up to 2 times according to the Digene-recommended algorithm. We studied 56 cervical samples in the retest zone. Specimens were tested by a multiplex polymerase chain reaction (PCR)-based genotyping assay, and relevant cytopathologic… CONTINUE READING

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