Evaluation of Wistar rats' individual sensitivity to the development of physical dependence on morphine.

@article{Sudakov1991EvaluationOW,
  title={Evaluation of Wistar rats' individual sensitivity to the development of physical dependence on morphine.},
  author={S. Sudakov and M. Konstantinopolsky and L. A. Surkova and I. Tyurina and E. Borisova},
  journal={Drug and alcohol dependence},
  year={1991},
  volume={29 1},
  pages={
          69-75
        }
}
Behavioral and physiological indices which could be symptoms of individual Wistar rats' sensitivity to the development of physical dependence on morphine, were studied. This state was induced in three different ways: (1) by i.p. injection of increasing doses of the drug; (2) by i.p. injection of morphine as a reward of a rat's visit to a certain compartment of the Y-maze; (3) by voluntary drinking a morphine solution. Animals with high sensitivity to the development of dependence induced by the… Expand
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