Evaluation of VCAM-1 antibodies as therapeutic agent for atherosclerosis in apolipoprotein E-deficient mice.

@article{Park2013EvaluationOV,
  title={Evaluation of VCAM-1 antibodies as therapeutic agent for atherosclerosis in apolipoprotein E-deficient mice.},
  author={Jong-Gil Park and Su Yeon Ryu and In-hyuk Jung and You-Han Lee and Kyung Jae Kang and M Lee and Mi-Ni Lee and Seong Keun Sonn and Jeong Hwa Lee and Hang Mei Lee and Goo Taeg Oh and KyungDuk Moon and Hyunbo Shim},
  journal={Atherosclerosis},
  year={2013},
  volume={226 2},
  pages={356-63}
}
OBJECTIVE Blocking agents targeting cell adhesion molecules have been developed to prevent cardiovascular diseases such as atherosclerosis, whereas relatively little attention has been paid to the therapeutic potential of vascular cell adhesion molecule (VCAM)-1 as an inflammatory disease target. Two novel, fully human antibodies, H6 and 7H, against human VCAM-1 (hVCAM-1) were developed and tested to validate the hypothesis that blocking VCAM-1 ameliorates atherosclerosis in apolipoprotein E… CONTINUE READING
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