Evaluation of Tracer Kinetic Models for Analysis of [18F]FDDNP Studies

  title={Evaluation of Tracer Kinetic Models for Analysis of [18F]FDDNP Studies},
  author={Maqsood Yaqub and Ronald Boellaard and Bart N. M. van Berckel and Nelleke Tolboom and Gert Luurtsema and Anke A. Dijkstra and Mark Lubberink and Albert D. Windhorst and Philip Scheltens and Adriaan A. Lammertsma},
  journal={Molecular Imaging and Biology},
  pages={322 - 333}
Different pharmacokinetic methods for [18F]FDDNP studies were evaluated using both simulations and clinical data. Methods included two-tissue reversible plasma (2T4k), simplified reference tissue input (SRTM), and a modified 2T4k models. The latter included an additional compartment for metabolites (2T1M). For plasma input models, binding potential, BPND, was obtained both directly (=k 3/k 4) and indirectly (using volume of distribution ratios). For clinical data, 2T1M was preferred over 2T4k… CONTINUE READING
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