Evaluation of THP-1 cell line as an in vitro model for long-term safety assessment of new molecules.

Abstract

OBJECTIVE Monitoring the chronic and subacute toxicity is essential in the development of new cosmetic ingredients. In response to the present lack of validated alternative methods, we developed an in vitro model for repeated dose cytotoxicity on THP-1 cells. METHODS Cultured in suspension, cells were treated with chemicals for 14 days with a frequency of… (More)
DOI: 10.1111/ics.12078

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