Evaluation of Safety and Immunogenicity of an Adjuvanted, TH-1 Skewed, Whole Virion InactivatedSARS-CoV-2 Vaccine - BBV152

  title={Evaluation of Safety and Immunogenicity of an Adjuvanted, TH-1 Skewed, Whole Virion InactivatedSARS-CoV-2 Vaccine - BBV152},
  author={Brunda Ganneru and Harsh Jogdand and Vijaya Kumar Dharam and Narasimha Reddy Molugu and Sai D. Prasad and Srinivas Vellimudu and Krishna M Ella and Rajaram Ravikrishnan and Amit Awasthi and Jomy Jose and P. Jayaprakash Rao and Deepak Kumar and Raches Ella and Priya Abraham and Pragya Dhruv Yadav and Gajanan N. Sapkal and Anita M Shete and Gururaj Rao Desphande and Sreelekshmy Mohandas and Atanu Basu and Nivedita Gupta and Krishna Mohan Vadrevu},
We report the development and evaluation of safety and immunogenicity of a whole virion inactivated SARS-COV-2 vaccine (BBV152), adjuvanted with aluminium hydroxide gel (Algel), or a novel TLR7/8 agonist adsorbed Algel. We used a well-characterized SARS-CoV-2 strain and an established vero cell platform to produce large-scale GMP grade highly purified inactivated antigen, BBV152. Product development and manufacturing were carried out in a BSL-3 facility. Immunogenicity was determined at two… Expand
Safety and immunogenicity clinical trial of an inactivated SARS-CoV-2 vaccine, BBV152 (a phase 2, double-blind, randomised controlled trial) and the persistence of immune responses from a phase 1 follow-up report
Interim findings of a controlled, randomised, double-blind trial on the immunogenicity and safety of BBV152, 3{ micro} and 6{micro} with Algel-IMDG suggest that the safety profile of this vaccine is noticeably lower than the rates for other SARS-CoV-2 vaccine platform candidates. Expand
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