Evaluation of SNPs in miR-196-a2, miR-27a and miR-146a as risk factors of colorectal cancer.

@article{Hezova2012EvaluationOS,
  title={Evaluation of SNPs in miR-196-a2, miR-27a and miR-146a as risk factors of colorectal cancer.},
  author={Renata Hezova and Alena Svobodov{\'a} Kovař{\'i}kov{\'a} and Julie Bienertov{\'a}-Va{\vs}ků and Milana Sachlova and Martina Redova and Anna Vasku and Marek Svoboda and Lenka Radov{\'a} and Igor Kiss and Rostislav Vyzula and Ondrej Slaby},
  journal={World journal of gastroenterology},
  year={2012},
  volume={18 22},
  pages={2827-31}
}
AIM To investigate whether selected single nucleotide polymorphisms (SNPs) in miR-196a2, miR-27a and miR-146a genes are associated with sporadic colorectal cancer (CRC). METHODS In order to investigate the effect of these SNPs in CRC, we performed a case-control study of 197 cases of sporadic CRC and 212 cancer-free controls originating from the Central-European Caucasian population using TaqMan Real-Time polymerase chain reaction and allelic discrimination analysis. RESULTS The genotype… CONTINUE READING

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