Several types of interventions in mental health have been implemented since the Psychiatric Reform to ensure assistance to the population affected by mental disorders. Psychiatric drugs and psychotropic agents are chemicals that act on the central nervous system and affect the mental and emotional functions of individuals. This study aimed to investigate the use of psychoactive substances of Ordinance 344/98 in the Psychiatric Emergency Service of the Hospital General Dr. Estevam Ponte (SEPHG). Research was conducted from January to March 2013. We analyzed the records of 30 admitted patients to SEPHG and their prescriptions. Of these, 20% of the patients came from the Center, 16.6% from Expectativa and 13.3% from Sinha Sabóia and Terrenos Novos, the remaining patients came from other districts of the city of Sobral. There was a higer higher prevalence of males (77%) who were administered psychotropic drugs. The prevalent age range was from 20 to 29 years, which corresponds to 33% in both sexes. The therapeutic classes that were dominant were typical antipsorics, such as haloperidol (96.6%) and benzodiazepines, such as diazepam (90%). There is concern with the use of psychotropic drugs and the need to implement services to ensure their rational use, preserving the health of the population and reducing public spending.