Evaluation of Portal/Peripheral Route and of Algorithms for Insulin Delivery in the Closed-Loop Control of Glucose in Diabetes - A Modeling Study

@article{Cobelli1983EvaluationOP,
  title={Evaluation of Portal/Peripheral Route and of Algorithms for Insulin Delivery in the Closed-Loop Control of Glucose in Diabetes - A Modeling Study},
  author={Claudio Cobelli and Alfredo Ruggeri},
  journal={IEEE Transactions on Biomedical Engineering},
  year={1983},
  volume={BME-30},
  pages={93-103}
}
In this paper we present an evaluation of portal versus peripheral routes for insulin delivery in diabetes with three representative closed-loop glucose control algorithms. A novel noninvasive approach is used which is based on a model of the blood glucose regulation system which simulates a Type I diabetic subject. The two routes and three algorithms are compared in controlling the simulated patient for 24 h, challenged with two dynamic glucose perturbations. The evaluation is performed by… CONTINUE READING