Evaluation of Physical and Chemical Changes in Pharmaceuticals Flown on Space Missions

@article{Du2011EvaluationOP,
  title={Evaluation of Physical and Chemical Changes in Pharmaceuticals Flown on Space Missions},
  author={Brian Du and Vernie R. Daniels and Zalman Vaksman and Jason L. Boyd and Camille Crady and Lakshmi Putcha},
  journal={The AAPS Journal},
  year={2011},
  volume={13},
  pages={299-308}
}
Efficacy and safety of medications used for the treatment of astronauts in space may be compromised by altered stability in space. We compared physical and chemical changes with time in 35 formulations contained in identical pharmaceutical kits stowed on the International Space Station (ISS) and on Earth. Active pharmaceutical content (API) was determined by ultra- and high-performance liquid chromatography after returning to Earth. After stowage for 28 months in space, six medications aboard… CONTINUE READING
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