Evaluation of Patterns of Liver Toxicity in Patients on Antiretroviral and Anti-Tuberculosis Drugs: A Prospective Four Arm Observational Study in Ethiopian Patients

@inproceedings{Yimer2014EvaluationOP,
  title={Evaluation of Patterns of Liver Toxicity in Patients on Antiretroviral and Anti-Tuberculosis Drugs: A Prospective Four Arm Observational Study in Ethiopian Patients},
  author={Getnet Yimer and Marcus Gry and Wondwossen Amogne and Eyasu Makonnen and Abiy Habtewold and Zelalem Petros and Getachew Aderaye and Ina Schuppe-Koistinen and Lars Lindquist and Eleni Aklillu},
  booktitle={PloS one},
  year={2014}
}
OBJECTIVES To evaluate the incidence, type, severity and predictors of antiretroviral and/or anti-tuberculosis drugs induced liver injury (DILI). METHODS A total of 1,060 treatment naive patients were prospectively enrolled into four treatment groups: HIV patients receiving efavirenz based HAART alone (Arm-1); TB-HIV co-infected patients with CD4≤200 cells/μL, receiving concomitant rifampicin based anti-TB and efavirenz based HAART (Arm-2); TB-HIV co-infected patients with CD4>200 cells/μL… CONTINUE READING
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Antiretroviral therapy for HIV infection in adults and adolescents : recommendations for a public health approach 2006 revision

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