Evaluation of PSI-BLAST alignment accuracy in comparison to structural alignments.

  title={Evaluation of PSI-BLAST alignment accuracy in comparison to structural alignments.},
  author={Iddo Friedberg and Tommy Kaplan and Hanah Margalit},
  journal={Protein science : a publication of the Protein Society},
  volume={9 11},
The PSI-BLAST algorithm has been acknowledged as one of the most powerful tools for detecting remote evolutionary relationships by sequence considerations only. This has been demonstrated by its ability to recognize remote structural homologues and by the greatest coverage it enables in annotation of a complete genome. Although recognizing the correct fold of a sequence is of major importance, the accuracy of the alignment is crucial for the success of modeling one sequence by the structure of… CONTINUE READING

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