Evaluation of PET radioligands for in vivo visualization of phosphodiesterase 5 (PDE5).

@article{Chekol2014EvaluationOP,
  title={Evaluation of PET radioligands for in vivo visualization of phosphodiesterase 5 (PDE5).},
  author={Rufael Chekol and Olivier Gheysens and Jan Cleynhens and Peter Pokreisz and Greet Vanhoof and M Sshibbir Ahamed and Stefan P. Janssens and Alfons Michel Verbruggen and Guy Bormans},
  journal={Nuclear medicine and biology},
  year={2014},
  volume={41 2},
  pages={155-62}
}
INTRODUCTION The cyclic guanosine monophosphate (cGMP) specific phosphodiesterase type 5 (PDE5) is considered to play an important role in various etiologies such as pulmonary arterial hypertension (PAH) and chronic heart failure. This PDE5 modulation represents an important prognostic and/or therapeutic target; however, there is currently no method to non-invasively evaluate the PDE5 expression levels in vivo. METHODS Radiolabeled tracers were prepared by N-alkylation of the corresponding… CONTINUE READING
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