Evaluation of Neonatal Streptozotocin Induced Diabetic Rat Model for the Development of Cataract

@inproceedings{Patil2014EvaluationON,
  title={Evaluation of Neonatal Streptozotocin Induced Diabetic Rat Model for the Development of Cataract},
  author={Madhoosudan A. Patil and P. V. Suryanarayana and Uday Kumar Putcha and Myadara Srinivas and G Bhanuprakash Reddy},
  booktitle={Oxidative medicine and cellular longevity},
  year={2014}
}
Type 2 diabetes (T2D) generally follows prediabetes (PD) conditions such as impaired fasting glucose (IFG) and/or impaired glucose tolerance (IGT). Although studies reported an association of IGT or IFG with cataract, the experimental basis for PD associated cataract is not known. Hence, we evaluated neonatal streptozotocin (nSTZ) induced rat model to study PD associated cataractogenesis by injecting STZ to two-day old rats. While majority (70%) of nSTZ injected pups developed IGT (nSTZ-PD) by… CONTINUE READING