Evaluation of NF2 and NF1 Tumor Suppressor Genes in Distinctive Gastrointestinal Nerve Sheath Tumors Traditionally Diagnosed as Benign Schwannomas: A Study of 20 Cases

@article{Lasota2003EvaluationON,
  title={Evaluation of NF2 and NF1 Tumor Suppressor Genes in Distinctive Gastrointestinal Nerve Sheath Tumors Traditionally Diagnosed as Benign Schwannomas: A Study of 20 Cases},
  author={Jerzy Lasota and Bartek Wasąg and Agnieszka Dansonka-Mieszkowska and Danuta Karcz and Carl L Millward and Janusz Ryś and Jerzy Stachura and Leslie H. Sobin and Markku Miettinen},
  journal={Laboratory Investigation},
  year={2003},
  volume={83},
  pages={1361-1371}
}
A significant percentage of conventional schwannomas, whether sporadic or associated with neurofibromatosis 2 (NF2), show loss of heterozygosity (LOH) at NF2 and/or NF2 inactivating mutations. Similarly, a significant percentage of neurofibromas show LOH at NF1 and/or NF1 inactivating mutations. There are no molecular genetic data on gastrointestinal (GI) nerve sheath tumors traditionally diagnosed as benign schwannomas, rare neoplasms possibly derived from the schwannian elements dispersed… CONTINUE READING

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