Evaluation of Iron Deficiency Using Reticulocyte Indices in Dogs Enrolled in a Blood Donor Program

  title={Evaluation of Iron Deficiency Using Reticulocyte Indices in Dogs Enrolled in a Blood Donor Program},
  author={Daniel S Foy and Kristen R. Friedrichs and Jonathan F Bach},
  journal={Journal of Veterinary Internal Medicine},
  pages={1376 - 1380}
Background People donating blood more than twice annually are at risk of developing iron deficiency. Little is known about the iron status of dogs enrolled in blood donor programs. Hypothesis Dogs donating blood ≥6 times annually will show evidence of iron deficiency based on their reticulocyte indices. Animals Thirteen dogs enrolled in a blood donor program donating ≥6 times over the preceding 12 months and 20 healthy nondonor control dogs. Methods Prospective observational study. Mature red… 
2 Citations
Evaluation of an intramuscular butorphanol and alfaxalone protocol for feline blood donation: a pilot study
The administration of IM alfaxalone and butorphanol provided sufficient restraint for blood donation without causing hypotension or significant changes in heart rate before or after phlebotomy.
Pigments: Iron and Friends.
Per Perl's Prussian Blue stain is used to highlight iron when these clues are not present, and basic iron metabolism, iron disorders in small animals, and laboratory assessment of iron disorders are presented.


Reticulocyte indices in a canine model of nutritional iron deficiency.
  • M. Fry, C. Kirk
  • Biology, Medicine
    Veterinary clinical pathology
  • 2006
Results of this study support the value of reticulocyte indices in the diagnosis and monitoring of ID in dogs and suggest species similarities in the pathophysiology and hematologic manifestations of ID suggest these findings also may be relevant to ID in people.
Effects of repeated blood donations on iron status and hematologic variables of canine blood donors.
All blood donation regimens induced a bone marrow regenerative response, which was able to restore depleted blood cells within 10 days after blood donation while maintaining iron status within the calculated reference range, however, dogs donating 13% of TBV every 2 months had a significant decrease in iron stores, which suggested that iron-related variables must be monitored during prolonged blood donor programs.
The Advia 120 red blood cell and reticulocyte indices are useful in diagnosis of iron‐deficiency anemia
The diagnostic efficiency provided by the red blood cell and reticulocyte indices was considerably lower in the heterogeneous group of hospitalized patients than in the group of female students, but may prove to be useful tools in the evaluation of iron status and diagnosis of iron‐deficiency anemia.
Evaluation of RBC ferritin and reticulocyte measurements in monitoring response to intravenous iron therapy.
Measurement of RBCFer and CHr provide evidence of increased iron supply for erythropoiesis during IV iron therapy, and help identify patients with functional iron deficiency and allow more accurate monitoring of response to IVIron therapy.
Iron Status in Blood Donor Dogs
The authors' canine BD population did not have iron deficiency and had higher SI concentration than C, however, ED developed a mild iron deficiency, although values were still within canine reference intervals.
Hematologic and biochemical abnormalities indicating iron deficiency are associated with decreased reticulocyte hemoglobin content (CHr) and reticulocyte volume (rMCV) in dogs.
Low CHr and low rMCV are associated with hematologic and serum biochemical abnormalities indicative of iron deficiency in canine patients and hold promise as noninvasive, cost-effective measures of iron status in the dog.
Iron deficiency anemia
Iron deficiency anemia (IDA) is the most common anemia syndrome encountered in clinical medicine, and in a recent review of healthy individuals in the US military, IDA had an incidence of 3.4 per 10,000 patient-years in men but 29.5 in women.
Effect of blood donation on iron stores as evaluated by serum ferritin.
It would appear that male donors, while depleting their iron stores, were able to donate 2-3 U/yr without an appreciable incidence of iron deficiency, and women could donate only about half that amount, and more frequent donations were associated with a high incidence ofIron deficiency and donor dropout.
Iron and blood donation.
Until clear-cut evidence is obtained of the deleterious effects of a lack of iron, the low prevalence of depleted iron reserves in men and non-menstruating women donors seems acceptable.
Iron stores in blood donors.
The total number of lifetime donations was not as predictive of decreased iron stores as frequency of donations per year, and even casual iron supplementation reduced the impact of donations on iron stores.