Evaluation of Irisin Levels and Epicardial Fat Thickness in Metabolic Syndrome

@article{Krbas2016EvaluationOI,
  title={Evaluation of Irisin Levels and Epicardial Fat Thickness in Metabolic Syndrome},
  author={Ozgur Kırbas and Ahmet G{\"o}ktuğ Ertem and Çağrı Yayla and Mehmet Kadri Akboga and Ayşe Kırbaş and O. Ozeke},
  journal={Journal of Clinical and Analytical Medicine},
  year={2016},
  volume={7},
  pages={497-500}
}
1 Özgür Kırbaş1, Ahmet Goktug Ertem1, Çağrı Yayla1, Mehmet Kadri Akboğa1, Ayse Kirbas2, Özcan Özeke1 1Department of Cardiology, Yüksek İhtisas Education and Research Hospital, 2Department of Perinatology, Zekai Tahir Burak Women’s Health Education and Research Hospital, Ankara, Turkey Irisin Levels and Epicardial Fat Thickness in Metabolic Syndrome Evaluation of Irisin Levels and Epicardial Fat Thickness in Metabolic Syndrome 
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Association of inflammation markers with epicardial adipose tissue in drug naïve metabolic syndrome

  • Özgür Kırbaş
  • Medicine, Biology
    Journal of Clinical and Analytical Medicine
  • 2018
The present study shows that both LMR and MHR may be novel and useful indicators of MetS, and there is an association among epicardial adipose tissue thickness, insulin resistance, lymphocyte to monocyte ratio (LMR) and monocyte count-to-high density lipoprotein cholesterol ratio (MHR) levels in drug naïve patient with metabolic syndrome.

17 References

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A systematic review of the literature finding associations of EF with metabolic syndrome and coronary artery disease concludes that EF is a visceral fat deposit with potential implications in coronary arteries disease.

Circulating irisin is lower in gestational diabetes mellitus.

The present cross-sectional investigation and meta-analysis is the first to show significant lower circulating irisin in subjects with GDM.

Meta-analysis of the relation of echocardiographic epicardial adipose tissue thickness and the metabolic syndrome.

Echocardiographic Epicardial Fat Thickness Is Associated with Carotid Intima‐Media Thickness in Patients with Metabolic Syndrome

EFT is associated with increased CIMT in patients with MetS, and the waist circumference, total and LDL‐cholesterol, fasting glucose, triglycerides, systolics and diastolic blood pressure levels, hs‐CRP, and homeostasis model assessment index for insulin resistance (HOMA‐IR) were significantly increased.

Maternal circulating levels of irisin in intrahepatic cholestasis of pregnancy

  • A. KırbaşK. Dağlar N. Danısman
  • Medicine
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
  • 2016
Serum irisin levels were significantly higher in women with ICP compared to healthy pregnant controls, suggesting that Irisin is a newly discovered myokine that is able to regulate glucose and lipid levels, thus improving insulin sensitivity.

Serum irisin levels in new-onset type 2 diabetes.

Epicardial Adipose Tissue Is Associated With Visceral Fat, Metabolic Syndrome, and Insulin Resistance in Menopausal Women

Exercise-induced irisin secretion is independent of age or fitness level and increased irisin may directly modulate muscle metabolism through AMPK activation.

In vitro experiments showed that irisin facilitates glucose and lipid metabolism in human muscle through AMP kinase phosphorylation, and exercise-induced irisin secretion is independent of age or fitness level.

Epicardial fat from echocardiography: a new method for visceral adipose tissue prediction.

Epicardial adipose tissue showed a strong correlation with anthropometric and imaging measurements of VAT, suggesting transthoracic echocardiography could be an easy and reliable imaging method for VAT prediction.

FNDC5/Irisin Is Not Only a Myokine but Also an Adipokine

This study reveals that rat skeletal muscle secretes a 25 kDa form of FNDC5, while the 12 kDa/irisin theoretical peptide was not detected, and is the first to reveal that white adipose tissue (WAT) also secretes F NDC5; hence, it may also behave as an adipokine.