Evaluation of Interindividual Human Variation in Bioactivation and DNA Adduct Formation of Estragole in Liver Predicted by Physiologically Based Kinetic/Dynamic and Monte Carlo Modeling.

@article{Punt2016EvaluationOI,
  title={Evaluation of Interindividual Human Variation in Bioactivation and DNA Adduct Formation of Estragole in Liver Predicted by Physiologically Based Kinetic/Dynamic and Monte Carlo Modeling.},
  author={Ans Punt and Alicia Paini and Albertus Spenkelink and Gabriele Scholz and Beno{\^i}t Schilter and Peter J. van Bladeren and Ivonne M C M Rietjens},
  journal={Chemical research in toxicology},
  year={2016},
  volume={29 4},
  pages={
          659-68
        }
}
Estragole is a known hepatocarcinogen in rodents at high doses following metabolic conversion to the DNA-reactive metabolite 1'-sulfooxyestragole. The aim of the present study was to model possible levels of DNA adduct formation in (individual) humans upon exposure to estragole. This was done by extending a previously defined PBK model for estragole in humans to include (i) new data on interindividual variation in the kinetics for the major PBK model parameters influencing the formation of 1… CONTINUE READING
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