• Corpus ID: 86069949

Evaluation of Hepatoprotective and Anti-oxidant Activity of Lemanea fluviatilis on CCl 4 Induced Hepatotoxicity Rats.

@inproceedings{Singh2014EvaluationOH,
  title={Evaluation of Hepatoprotective and Anti-oxidant Activity of Lemanea fluviatilis on CCl 4 Induced Hepatotoxicity Rats.},
  author={I Singh and Palayyan Muralidharan},
  year={2014}
}

• I. Singh, P. Muralidharan
• Published 2014
• Biology, Chemistry

The aim of our present study is to assess the effect of Lemanea fluviatilis as a hepatoprotective activity in experimental induced hepatotoxic model in rats. Hepatotoxicity were induced by single dose of carbon tetrachloride which generates free radicals, responsible for the degeneration of liver. Increase concentration of hepatic biochemical markers like Aspartate AminoTransferase (AST), Alanine Amino Transferase (ALT), Alkaline Phosphatase (ALP), Total Bilirubin (TB), Total protein (TP), Triglycerides (TG), Gammaglutamyltransferase (GGT) levels are considered as hepatotoxicities. Administration of Hydroalcoholic extract of Lemanea fluviatilis (100, 250, 500 mg/kg) orally for 27 days caused a significant reduction in Lipid peroxidation, Aspartate Aminotransferase, Alanine Aminotransferase, Alkaline Phosphatase, cholesterol and triglyceride levels as compared to animals which received saline water. The hepatoprotective activity was also supported by histopathalogical studies of the liver.